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pentobarbital will reduce the level or impact of cyclosporine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.Observe Closely (1)pentobarbital will lessen the extent or result of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Loss of, or decreased response to tofaciti